Jump to main content
Jump to site search

Issue 83, 2020
Previous Article Next Article

A base-repair based electrochemiluminescent genotoxicity sensor that detects abasic sites in double-stranded DNA films

Author affiliations

Abstract

A novel genotoxicity sensor was developed based on the base repair process associated with the electrochemiluminescence (ECL) detection of abasic sites in a double-stranded DNA monolayer. This is the first time that an ECL sensor with the ability to identify the removed nucleobases in a DNA duplex has been studied. The successful detection of abasic sites created by DNA glycosylase indicates its further applications for examining some other specific types of DNA damage.

Graphical abstract: A base-repair based electrochemiluminescent genotoxicity sensor that detects abasic sites in double-stranded DNA films

Back to tab navigation

Supplementary files

Article information


Submitted
31 Jul 2020
Accepted
07 Sep 2020
First published
09 Sep 2020

Chem. Commun., 2020,56, 12558-12561
Article type
Communication

A base-repair based electrochemiluminescent genotoxicity sensor that detects abasic sites in double-stranded DNA films

D. Wang, J. Jia, R. Huang and X. Zhang, Chem. Commun., 2020, 56, 12558
DOI: 10.1039/D0CC05186A

Social activity

Search articles by author

Spotlight

Advertisements