Biomimetic systems involving sequential redox reactions in glycolysis – the sulfur effect

Narihito Ogawa; Sei Furukawa; Yuya Kosugi; Takayuki Takazawa; Nobuhiro Kanomata

doi:10.1039/D0CC05185C

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Biomimetic systems involving sequential redox reactions in glycolysis – the sulfur effect†

Narihito Ogawa,

*^a Sei Furukawa,^b Yuya Kosugi,^a Takayuki Takazawa^a and Nobuhiro Kanomata

*^b

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* Corresponding authors

^a Department of Applied Chemistry, Meiji University, Kawasaki, Kanagawa 214-8571, Japan
E-mail: narihito@meiji.ac.jp

^b Department of Chemistry and Biochemistry, Waseda University, Shinjuku-ku, Tokyo 169-8555, Japan
E-mail: kanomata@waseda.jp

Abstract

Magnesium hemithioacetates were used as model cysteine compounds to mimic natural hemithioacetals, and their biomimetic oxidation reactions using a model NAD⁺ compound were investigated. Cyclic hemithioacetate was found to be the best substrate for the reaction with the model NAD⁺ compound, which gave the corresponding NADH analog in excellent yield.

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Article information

DOI: https://doi.org/10.1039/D0CC05185C
Article type: Communication
Submitted: 30 Jul 2020
Accepted: 17 Sep 2020
First published: 25 Sep 2020

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Chem. Commun., 2020,56, 12917-12920

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Biomimetic systems involving sequential redox reactions in glycolysis – the sulfur effect

N. Ogawa, S. Furukawa, Y. Kosugi, T. Takazawa and N. Kanomata, Chem. Commun., 2020, 56, 12917 DOI: 10.1039/D0CC05185C

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Chemical Communications

Biomimetic systems involving sequential redox reactions in glycolysis – the sulfur effect†

Abstract

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Biomimetic systems involving sequential redox reactions in glycolysis – the sulfur effect

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