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Catechols: a new class of carbonic anhydrase inhibitors

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Abstract

To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the “deep water”.

Graphical abstract: Catechols: a new class of carbonic anhydrase inhibitors

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Article information


Submitted
29 Jul 2020
Accepted
21 Sep 2020
First published
21 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Catechols: a new class of carbonic anhydrase inhibitors

K. D'Ambrosio, S. Carradori, S. Cesa, A. Angeli, S. M. Monti, C. T. Supuran and G. De Simone, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05172A

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