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Issue 86, 2020
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Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations

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Abstract

Spontaneously blinking fluorophores are powerful tools for live-cell super-resolution imaging under physiological conditions. Here we show that quantum-chemical calculations can predict key parameters for fluorophore design. We applied this methodology to develop a spontaneously blinking fluorophore with yellow fluorescence for super-resolution imaging of microtubules in living cells.

Graphical abstract: Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations

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Article information


Submitted
28 Jul 2020
Accepted
24 Sep 2020
First published
25 Sep 2020

Chem. Commun., 2020,56, 13173-13176
Article type
Communication

Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations

R. Tachibana, M. Kamiya, A. Morozumi, Y. Miyazaki, H. Fujioka, A. Nanjo, R. Kojima, T. Komatsu, T. Ueno, K. Hanaoka, T. Yoshihara, S. Tobita and Y. Urano, Chem. Commun., 2020, 56, 13173
DOI: 10.1039/D0CC05126H

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