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Issue 84, 2020
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Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

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Abstract

A key goal of modular polyketide synthase (PKS) engineering is to alter polyketide stereochemistry. Here we report that exchanging whole PKS modules is a more productive approach than swapping individual ketoreductase (KR) domains for introducing rare ‘A2’ and ‘B2’ stereochemistry into model polyketides, and identify four modular ‘biobricks’ for such synthetic biology efforts.

Graphical abstract: Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

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Article information


Submitted
24 Jul 2020
Accepted
30 Aug 2020
First published
04 Sep 2020

Chem. Commun., 2020,56, 12749-12752
Article type
Communication

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

J. Massicard, C. Soligot, K. J. Weissman and C. Jacob, Chem. Commun., 2020, 56, 12749
DOI: 10.1039/D0CC05068G

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