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Issue 84, 2020
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Cascade signal amplification for sensitive detection of exosomes by integrating tyramide and surface-initiated enzymatic polymerization

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Abstract

A novel cascade signal amplification based on tyramide signal amplification (TSA) and surface-initiated enzymatic polymerization (SIEP) was first reported for the sensitive and template-free detection of colorectal cancer (CRC) exosomes. This assay exhibited 20.9-fold signal amplification with a low detection limit of 12.8 particles per μL. Furthermore, accurate and reproducible results were obtained for detecting exosomes in serum samples, suggesting its potential application in exosomes analysis and clinical diagnostics.

Graphical abstract: Cascade signal amplification for sensitive detection of exosomes by integrating tyramide and surface-initiated enzymatic polymerization

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Supplementary files

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Submitted
16 Jul 2020
Accepted
15 Sep 2020
First published
16 Sep 2020

Chem. Commun., 2020,56, 12793-12796
Article type
Communication

Cascade signal amplification for sensitive detection of exosomes by integrating tyramide and surface-initiated enzymatic polymerization

Z. Huang, Q. Lin, B. Yang, X. Ye, H. Chen, W. Weng and J. Kong, Chem. Commun., 2020, 56, 12793
DOI: 10.1039/D0CC04881J

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