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Issue 78, 2020
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Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III

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Abstract

In recent years, liquid–liquid phase separation (LLPS) has emerged as a key mechanism for intracellular organization. But there is rapidly growing evidence that LLPS may also be associated with a number of medical conditions, including neurodegenerative diseases, by acting as a modulator of pathological protein aggregation. Here we show how LLPS formed by the P-granule protein LAF-1 and RNA can be affected by antimicrobial peptides, such as LL-III, leading to enhanced formation of amorphous protein aggregates and the loss of droplet function as an efficient reaction center and organizational hub.

Graphical abstract: Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III

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Supplementary files

Article information


Submitted
15 Jul 2020
Accepted
04 Sep 2020
First published
04 Sep 2020

This article is Open Access

Chem. Commun., 2020,56, 11577-11580
Article type
Communication

Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III

R. Oliva, S. K. Mukherjee, Z. Fetahaj, S. Möbitz and R. Winter, Chem. Commun., 2020, 56, 11577
DOI: 10.1039/D0CC04877A

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    [Original citation] - Published by The Royal Society of Chemistry.

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