Rosario Oliva, Sanjib K. Mukherjee, Zamira Fetahaj, Simone Möbitz and Roland Winter
Chem. Commun., 2020,56, 11577-11580
DOI:
10.1039/D0CC04877A,
Communication
In recent years, liquid–liquid phase separation (LLPS) has emerged as a key mechanism for intracellular organization. But there is rapidly growing evidence that LLPS may also be associated with a number of medical conditions, including neurodegenerative diseases, by acting as a modulator of pathological protein aggregation. Here we show how LLPS formed by the P-granule protein LAF-1 and RNA can be affected by antimicrobial peptides, such as LL-III, leading to enhanced formation of amorphous protein aggregates and the loss of droplet function as an efficient reaction center and organizational hub.