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Small molecule induced toxic human-IAPP species characterized by NMR

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Abstract

In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1–40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.

Graphical abstract: Small molecule induced toxic human-IAPP species characterized by NMR

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Article information


Submitted
13 Jul 2020
Accepted
23 Sep 2020
First published
23 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Small molecule induced toxic human-IAPP species characterized by NMR

S. J. Cox, D. C. Rodriguez Camargo, Y. Lee, R. C. A. Dubini, P. Rovó, M. I. Ivanova, V. Padmini, B. Reif and A. Ramamoorthy, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC04803H

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