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Issue 76, 2020
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Recent advances in the development of anti-infective peptoids

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Abstract

In the search for new sources of antimicrobials many researchers have investigated antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics. However, efforts to develop AMPs in this area has been severely hampered by their inherent susceptibility to enzymatic degradation. Given this only a handful of AMPs are currently in clinical trials. Peptide mimetics such as peptoids have emerged as highly promising alternatives to AMPs as they are inherently stable to enzymatic degradation and display potent antimicrobial properties. This feature article highlights the progress that has been made towards the development of novel anti-infective peptoids.

Graphical abstract: Recent advances in the development of anti-infective peptoids

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Article information


Submitted
07 Jul 2020
Accepted
24 Aug 2020
First published
28 Aug 2020

Chem. Commun., 2020,56, 11158-11168
Article type
Feature Article

Recent advances in the development of anti-infective peptoids

K. L. Bicker and S. L. Cobb, Chem. Commun., 2020, 56, 11158
DOI: 10.1039/D0CC04704J

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