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pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

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Abstract

The dynamic Schiff base bond is exploited to construct monodisperse dopamine-based nanoparticles with autofluorescence and pH-sensitivity. This allows facile monitoring and pH-responsive drug release in the acidic tumor microenvironment. Anticancer drugs doxorubicin and a photosensitizer chlorin e6 are further loaded into the nanoparticles and synergistic anticancer efficacy is achieved.

Graphical abstract: pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

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Article information


Submitted
06 Jul 2020
Accepted
25 Sep 2020
First published
26 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

H. Li, Y. Zhao, Y. Jia, G. Chen, J. Peng and J. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC04656F

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