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Abstract | Cited by

A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.

Graphical abstract: Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

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