A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.
Y. Zhang, A. Gambardella, M. Üçüncü, J. Geng, J. Clavadetscher, M. Bradley and A. Lilienkampf, Chem. Commun., 2020, 56, 13856 DOI: 10.1039/D0CC04591H
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