Ligand regulation for manganese-catalyzed enantioselective epoxidation of olefins without acid†
A novel manganese catalyst bearing an L-proline-derived N4 ligand has been developed for enabling acid-free asymmetric epoxidation of olefins with tert-butyl hydroperoxide as the oxidant. A variety of olefins that are well-matched in size with the ligand pocket can be transformed to epoxides with excellent enantioselectivities. The smaller ligand pocket is also beneficial to the enantioselective epoxidation of simple olefins. Cryospray ionization mass spectrometry experiments reveal that a MnIVO species serves as an active epoxidizing species.
- This article is part of the themed collection: Bioinspired metal complexes for chemical transformations and catalysis