A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies

Shuang Chao; Xiukai Lv; Ning Ma; Ziyan Shen; Feiyu Zhang; Yuxin Pei; Zhichao Pei

doi:10.1039/D0CC04315J

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A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies†

Shuang Chao,^a Xiukai Lv,^a Ning Ma,^a Ziyan Shen,^a Feiyu Zhang,^a Yuxin Pei

^a and Zhichao Pei

*^a

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* Corresponding authors

^a Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China
E-mail: peizc@nwafu.edu.cn
Fax: +86-29-8709-2769
Tel: +86-29-8709-2769

Abstract

A supramolecular nanoprodrug based on the host–guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells. In vitro studies revealed that the Dox-loaded WP5G–Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.

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Article information

DOI: https://doi.org/10.1039/D0CC04315J
Article type: Communication
Submitted: 22 Jun 2020
Accepted: 29 Jun 2020
First published: 01 Jul 2020

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Chem. Commun., 2020,56, 8861-8864

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A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies

S. Chao, X. Lv, N. Ma, Z. Shen, F. Zhang, Y. Pei and Z. Pei, Chem. Commun., 2020, 56, 8861 DOI: 10.1039/D0CC04315J

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Chemical Communications

A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies†

Abstract

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A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies

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