Issue 80, 2020

B(C6F5)3-Catalyzed cyclization of alkynes: direct synthesis of 3-silyl heterocyclic compounds

Abstract

An efficient one-pot strategy for easy access to 3-silyl heterocyclic compounds was developed via a B(C6F5)3-catalyzed cycloaddition reaction of o-(1-alkynyl)(thio)anisoles or o-(1-alkynyl)-N-methylaniline. In this reaction, benzenethiophene, benzofuran or indole skeletons could be constructed by an intermolecular cyclization with diphenylsilane. This protocol elicited moderate-to-good yields with metal-free reaction systems.

Graphical abstract: B(C6F5)3-Catalyzed cyclization of alkynes: direct synthesis of 3-silyl heterocyclic compounds

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2020
Accepted
19 Aug 2020
First published
21 Aug 2020

Chem. Commun., 2020,56, 11953-11956

B(C6F5)3-Catalyzed cyclization of alkynes: direct synthesis of 3-silyl heterocyclic compounds

M. Li, T. Wang, Z. An and R. Yan, Chem. Commun., 2020, 56, 11953 DOI: 10.1039/D0CC04314A

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