Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical†
Product analysis from the iron Fenton oxidation of 2′-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2′-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙−. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.
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