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Issue 68, 2020
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Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical

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Abstract

Product analysis from the iron Fenton oxidation of 2′-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2′-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.

Graphical abstract: Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical

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Article information


Submitted
13 Jun 2020
Accepted
21 Jul 2020
First published
21 Jul 2020

Chem. Commun., 2020,56, 9779-9782
Article type
Communication

Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical

A. M. Fleming and C. J. Burrows, Chem. Commun., 2020, 56, 9779
DOI: 10.1039/D0CC04138F

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