Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Rhodium-catalyzed regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes

Author affiliations

Abstract

A rhodium-catalyzed asymmetric allylic alkylation of pyrazol-5-ones with internal alkynes is illustrated. In the presence of a chiral rhodium-hydride catalyst, functionalized heterocyclic products bearing an all-carbon quaternary stereogenic center were obtained in high yields with satisfactory enantioselectivities. This protocol also features good regiocontrol and a high atom economy without stoichiometric by-product formation.

Graphical abstract: Rhodium-catalyzed regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes

Back to tab navigation

Supplementary files

Article information


Submitted
08 Jun 2020
Accepted
18 Jun 2020
First published
19 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Rhodium-catalyzed regio- and enantioselective allylic alkylation of pyrazol-5-ones with alkynes

D. Ji, F. Yang, B. Chen, X. Min, C. Kuai, Y. Hu and Q. Chen, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC04002A

Social activity

Search articles by author

Spotlight

Advertisements