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Issue 64, 2020
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Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

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Abstract

15N spin–lattice relaxation dynamics in metronidazole-15N3 and metronidazole-15N2 isotopologues are studied for rational design of 15N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14N nucleus within the spin-relayed 15N–15N network.

Graphical abstract: Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

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Article information


Submitted
08 May 2020
Accepted
30 Jun 2020
First published
14 Jul 2020

Chem. Commun., 2020,56, 9098-9101
Article type
Communication

Quantifying the effects of quadrupolar sinks via15N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH

J. R. Birchall, M. S. H. Kabir, O. G. Salnikov, N. V. Chukanov, A. Svyatova, K. V. Kovtunov, I. V. Koptyug, J. G. Gelovani, B. M. Goodson, W. Pham and E. Y. Chekmenev, Chem. Commun., 2020, 56, 9098
DOI: 10.1039/D0CC03994B

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