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Issue 69, 2020
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A matrix metalloproteinase activation probe for painting human tumours

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Abstract

A probe that allows specific ‘painting’ of human tumours is described. Probe activation was mediated by specific matrix metalloproteinases, resulting not only in disruption of a FRET pair, but in the generation of a fragment that “fluorescently paints” human tumours. This probe demonstrated rapid and effective human tumour labelling with the potential to allow margin detection during surgical resection.

Graphical abstract: A matrix metalloproteinase activation probe for painting human tumours

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Supplementary files

Article information


Submitted
03 Jun 2020
Accepted
14 Jul 2020
First published
16 Jul 2020

This article is Open Access

Chem. Commun., 2020,56, 9962-9965
Article type
Communication

A matrix metalloproteinase activation probe for painting human tumours

B. Mills, D. Norberg, K. Dhaliwal, A. R. Akram, M. Bradley and A. Megia-Fernandez, Chem. Commun., 2020, 56, 9962
DOI: 10.1039/D0CC03886E

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