Issue 80, 2020

Tetrazine metallation boosts rate and regioselectivity of inverse electron demand Diels–Alder (iEDDA) addition of dienophiles

Abstract

Reported herein is the coordination of rhenium complexes to tetrazine ligand in [ReCl(CO)3(TzPy)] [1] (TzPy = 3-(2-pyridyl)-1,2,4,5-tetrazine) and the rates of addition of different dienophiles to the tetrazine. Tetrazine coordiation lowers the ΔS contribution to ΔG for iEDDA addition.

Graphical abstract: Tetrazine metallation boosts rate and regioselectivity of inverse electron demand Diels–Alder (iEDDA) addition of dienophiles

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2020
Accepted
05 Aug 2020
First published
09 Sep 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 12033-12036

Tetrazine metallation boosts rate and regioselectivity of inverse electron demand Diels–Alder (iEDDA) addition of dienophiles

M. Schnierle, S. Blickle, V. Filippou and M. R. Ringenberg, Chem. Commun., 2020, 56, 12033 DOI: 10.1039/D0CC03805A

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