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Issue 70, 2020
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Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

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Abstract

Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.

Graphical abstract: Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

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Article information


Submitted
28 May 2020
Accepted
16 Jul 2020
First published
17 Jul 2020

Chem. Commun., 2020,56, 10127-10130
Article type
Communication

Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

L. Wan, S. L. Lam, H. K. Lee and P. Guo, Chem. Commun., 2020, 56, 10127 DOI: 10.1039/D0CC03774E

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