Issue 62, 2020
From the journal:

Chemical Communications

Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool†

Longjie Li,‡ab   Wenkai Zhang,‡ac   Xiaofeng Tang,a   Zejian Li,a   Yuzhou Wu*b  and  Xianjin Xiao ORCID logo *ac  

* Corresponding authors

a Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
E-mail: xiaoxianjin@hust.edu.cn

b Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
E-mail: wuyuzhou@hust.edu.cn

c Department of Obstetrics and Gynaecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Abstract

A wedge-like tool was established to finely and bidirectionally regulate the displacement rate of toehold-mediated strand displacement. This novel tool is very robust in terms of sequence generality and is compatible with most of the current DNA nanodevices based on traditional toehold reactions.

Graphical abstract: Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool

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Article information

DOI
https://doi.org/10.1039/D0CC03722B
Article type
Communication
Submitted
26 May 2020
Accepted
25 Jun 2020
First published
25 Jun 2020

Chem. Commun., 2020,56, 8794-8797

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Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool

L. Li, W. Zhang, X. Tang, Z. Li, Y. Wu and X. Xiao, Chem. Commun., 2020, 56, 8794 DOI: 10.1039/D0CC03722B

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