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Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

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Abstract

Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2* contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications.

Graphical abstract: Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

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Supplementary files

Article information


Submitted
21 May 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

W. Zhang, H. Choi, B. Yu and D. Kim, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03614E

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