Synthesis of Iron Oxide Nanocubes Patched Janus Magnetic Nanocarriers for Cancer Therapeutic Applications
Janus magnetic particles, which can be customizable for various multifunctionalities, have a promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocubes (IONCs) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONCs patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONCs patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONCs patched Janus nanocarriers, allowing effective MRI T2* contrast and magneto-mechanical property, are expected to be used for a new type of multifunctional carriers in cancer therapeutic applications.