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In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

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Abstract

Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice. Our study provides an improved strategy to promote in vivo fluorescence imaging applications in early-stage clinical diagnosis.

Graphical abstract: In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

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Article information


Submitted
20 May 2020
Accepted
24 Jun 2020
First published
24 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

H. Wu, W. Zhou, L. Liu, Z. Fan, H. Tang, R. Yu and J. Jiang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03596C

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