Issue 62, 2020

In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

Abstract

Herein, we develop a novel tripartite DNA probe to transport phosphorothioated substrate hairpins and an aptamer for the intramolecular CHA circuit, which achieves detection of a low amount of specific mRNA in living cells and mice. Our study provides an improved strategy to promote in vivo fluorescence imaging applications in early-stage clinical diagnosis.

Graphical abstract: In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2020
Accepted
24 Jun 2020
First published
24 Jun 2020

Chem. Commun., 2020,56, 8782-8785

In vivo mRNA imaging based on tripartite DNA probe mediated catalyzed hairpin assembly

H. Wu, W. Zhou, L. Liu, Z. Fan, H. Tang, R. Yu and J. Jiang, Chem. Commun., 2020, 56, 8782 DOI: 10.1039/D0CC03596C

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