An MRI-visible immunoadjuvant based on hollow Gd2O3 nanospheres for cancer immunotherapy

Xia Li; Xiupeng Wang; Atsuo Ito

doi:10.1039/D0CC03568H

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An MRI-visible immunoadjuvant based on hollow Gd₂O₃ nanospheres for cancer immunotherapy†

Xia Li,^a Xiupeng Wang

*^a and Atsuo Ito^a

Author affiliations

* Corresponding authors

^a Health and Medical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
E-mail: xp-wang@aist.go.jp

Abstract

Hollow Gd₂O₃ nanospheres significantly promote the cellular uptake of a tumor antigen by antigen presenting cells, exhibit pH-dependent alteration of the MR signal intensity and markedly enhance the antitumor immunity. Hollow Gd₂O₃ nanospheres are promising as magnetic resonance imaging (MRI)-visible cancer immunoadjuvants for cancer immunotherapy.

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Article information

DOI: https://doi.org/10.1039/D0CC03568H
Article type: Communication
Submitted: 19 May 2020
Accepted: 22 Jun 2020
First published: 22 Jun 2020

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Chem. Commun., 2020,56, 8186-8189

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An MRI-visible immunoadjuvant based on hollow Gd₂O₃ nanospheres for cancer immunotherapy

X. Li, X. Wang and A. Ito, Chem. Commun., 2020, 56, 8186 DOI: 10.1039/D0CC03568H

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Chemical Communications