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Issue 68, 2020
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Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

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Abstract

Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.

Graphical abstract: Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

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Supplementary files

Article information


Submitted
18 May 2020
Accepted
21 Jul 2020
First published
30 Jul 2020

This article is Open Access

Chem. Commun., 2020,56, 9787-9790
Article type
Communication

Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

Y. P. Y. Lam, C. K. C. Chiu, C. A. Wootton, I. Hands-Portman, M. Li, M. P. Barrow and P. B. O'Connor, Chem. Commun., 2020, 56, 9787
DOI: 10.1039/D0CC03548C

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