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Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

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Abstract

A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. The as-fabricated Au10NC-PAH realized effective antibody-mediated actin imaging and sustained drug release.

Graphical abstract: Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

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Supplementary files

Article information


Submitted
16 May 2020
Accepted
22 Jun 2020
First published
23 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

M. Xu, T. Jia, B. Li, W. Ma, X. Chen, X. Zhao and S. Zang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03498C

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