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Multicomponent Benzannulation of Allylic P-ylides with Isocyanates or Aldehydes for Construction of Anilines and Biaryls

Abstract

The reactivity of allylic phosphorus ylides generated in situ from alkoxycarbonylmethylenephosphoranes and propiolates is investigated toward isocyanates and aromatic aldehydes, which leads to one-pot multicomponent benzannulations for efficient synthesis of polysubstituted anilines and biaryls, respectively. The mechanism may involve a tandem [2+2] cycloaddition/fragmentation/Wittig/cyclization/elimination/aromatization sequence.

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Article information


Submitted
15 May 2020
Accepted
28 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Multicomponent Benzannulation of Allylic P-ylides with Isocyanates or Aldehydes for Construction of Anilines and Biaryls

R. B. Kaki, Y. Li, W. Xu, Y. Tang, W. Zhang and S. Xu, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC03461D

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