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Single Nucleotide Variant Discrimination by Toehold Exchange Spherical Nucleic Acids Modulated on Hierarchical Molybdenum Disulfide Acanthosphere

Abstract

A toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthosphere was proposed for single nucleotide variants (SNVs) discrimination. We rationally optimized the probe by making a trade-off between discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

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Article information


Submitted
13 May 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Single Nucleotide Variant Discrimination by Toehold Exchange Spherical Nucleic Acids Modulated on Hierarchical Molybdenum Disulfide Acanthosphere

M. Zhu, Y. Yu, J. Zhu, Y. Zhou, G. Su, H. Zhu, Y. Chen and M. Liu, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC03425H

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