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Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry

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Abstract

We introduce an innovative approach to adhere mesenchymal stem cells (MSCs) to a hydrogel scaffold by nucleating adhesion through strain-promoted click chemistry. This method yields a significant increase in cell viability compared to non-functionalized and RGD peptide functionalized hydrogels, providing a promising alternative to traditional biomaterials cell attachment approaches.

Graphical abstract: Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry

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Article information


Submitted
11 May 2020
Accepted
28 May 2020
First published
29 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Inducing mesenchymal stem cell attachment on non-cell adhesive hydrogels through click chemistry

A. Battigelli, B. Almeida, S. Shukla, A. D. Rocha and A. Shukla, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03403G

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