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Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

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Abstract

A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe [1 with combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, [1 with combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.

Graphical abstract: Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

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Supplementary files

Article information


Submitted
12 May 2020
Accepted
29 May 2020
First published
29 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(II) superoxide dismutase mimic complex

E. Mathieu, A. Bernard, E. Quévrain, M. Zoumpoulaki, S. Iriart, C. Lung-Soong, B. Lai, K. Medjoubi, L. Henry, S. Nagarajan, F. Poyer, A. Scheitler, I. Ivanović-Burmazović, S. Marco, A. Somogyi, P. Seksik, N. Delsuc and C. Policar, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03398G

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