Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(II) superoxide dismutase mimic complex

Emilie Mathieu; Anne-Sophie Bernard; Elodie Quévrain; Martha Zoumpoulaki; Sébastien Iriart; Caroline Lung-Soong; Barry Lai; Kadda Medjoubi; Lucas Henry; Sounderya Nagarajan; Florent Poyer; Andreas Scheitler; Ivana Ivanović-Burmazović; Sergio Marco; Andrea Somogyi; Philippe Seksik; Nicolas Delsuc; Clotilde Policar

doi:10.1039/D0CC03398G

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex†

Emilie Mathieu,^a Anne-Sophie Bernard,^a Elodie Quévrain,^a Martha Zoumpoulaki,^a Sébastien Iriart,^a Caroline Lung-Soong,^a Barry Lai,^b Kadda Medjoubi,^c Lucas Henry,^a Sounderya Nagarajan,^de Florent Poyer,^de Andreas Scheitler,

^f Ivana Ivanović-Burmazović,^f Sergio Marco,^de Andrea Somogyi,

^c Philippe Seksik,^g Nicolas Delsuc

^a and Clotilde Policar

*^a

Author affiliations

* Corresponding authors

^a Laboratoire des biomolécules, LBM, Département de chimie, Ecole normale supérieure, PSL University, Sorbonne université, CNRS, 75005 Paris, France
E-mail: clotilde.policar@ens.fr

^b X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA

^c Synchrotron SOLEIL, BP 48, Saint-Aubin, 91192 Gif sur Yvette, France

^d Institut Curie, Research Center, PSL University, Chemistry, Modelling and Imaging for Biology (CMIB), Bât 110-112, Centre Universitaire, F-910405 Orsay, France

^e INSERM U 1196, CNRS UMR 9187, Paris-Saclay University, Paris-Sud University, University Centre, Orsay, France

^f Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Egerlandstr. 1, 91058 Erlangen, Germany

^g Sorbonne Université, Ecole normale supérieure, PSL University, CNRS, INSERM, AP-HP, Laboratoire des biomolécules, LBM, 75012 Paris, France

Abstract

A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.

Chemical Communications

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex†

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Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(II) superoxide dismutase mimic complex

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