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Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

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Abstract

A facile enzymatic modular assembly strategy for the preparative-scale synthesis of poly-N-acetyllactosamine (poly-LacNAc) glycans with varied lengths and designed sialylation and/or fucosylation patterns is described. These glycans were printed as a microarray to investigate their interactions with a panel of glycan binding proteins (GBPs). Binding affinities revealed that the avidity of GBPs could be largely affected by the length and the patterns of sialylation and fucosylation.

Graphical abstract: Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

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Supplementary files

Article information


Submitted
06 May 2020
Accepted
15 Jun 2020
First published
15 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

C. Chen, S. Wang, M. R. Gadi, H. Zhu, F. Liu, C. Liu, L. Li, F. Wang, P. Ling and H. Cao, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03268A

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