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Issue 55, 2020
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Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

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Abstract

A facile enzymatic modular assembly strategy for the preparative-scale synthesis of poly-N-acetyllactosamine (poly-LacNAc) glycans with varied lengths and designed sialylation and/or fucosylation patterns is described. These glycans were printed as a microarray to investigate their interactions with a panel of glycan binding proteins (GBPs). Binding affinities revealed that the avidity of GBPs could be largely affected by the length and the patterns of sialylation and fucosylation.

Graphical abstract: Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

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Submitted
06 May 2020
Accepted
15 Jun 2020
First published
15 Jun 2020

Chem. Commun., 2020,56, 7549-7552
Article type
Communication

Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives

C. Chen, S. Wang, M. R. Gadi, H. Zhu, F. Liu, C. Liu, L. Li, F. Wang, P. Ling and H. Cao, Chem. Commun., 2020, 56, 7549
DOI: 10.1039/D0CC03268A

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