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Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies†

Vikash Kumar,a   Oyuntuya Munkhbat,a   Hatice Secinti ORCID logo a  and  S. Thayumanavan ORCID logo *abc  
Author affiliations

* Corresponding authors

a Department of Chemistry, University of Massachusetts, Amherst, MA-01003, USA
E-mail: thai@umass.edu

b Centre for Bioactive Delivery, Institute for Applied Life Science, University of Massachusetts, Amherst, MA-01003, USA

c Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA-01003, USA

Abstract

Alkaline phosphatase (ALP) responsive polymers, which can unzip from head to tail are reported. Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggered disassembly kinetics.

Graphical abstract: Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies

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Article information

https://doi.org/10.1039/D0CC03257C
Submitted
06 May 2020
Accepted
17 Jun 2020
First published
17 Jun 2020
Chem. Commun., 2020, Advance Article
Article type
Communication
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Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies

V. Kumar, O. Munkhbat, H. Secinti and S. Thayumanavan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03257C

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