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Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides

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Abstract

A H2O mediated practical and highly regioselective chloro- and bromo-trifluoromethylthiolation of sulfur ylides is reported using a difunctionalization strategy. In the reaction sequence, sulfur ylides presumably react with an electrophilic trifluoromethylthiolating reagent to generate an α-SCF3 substituted sulfonium salt intermediate, which then undergoes a substitution with nucleophilic halogens.

Graphical abstract: Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides

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Article information


Submitted
02 May 2020
Accepted
11 Jun 2020
First published
11 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides

H. Qin, Y. Jia, N. Wang, Z. Jiang and Z. Yang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03171B

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