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Issue 55, 2020
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Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

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Abstract

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

Graphical abstract: Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

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Supplementary files

Article information


Submitted
01 May 2020
Accepted
23 May 2020
First published
25 May 2020

Chem. Commun., 2020,56, 7573-7576
Article type
Communication

Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

S. Li, Z. Wang, H. Xiao, Z. Bian and J. (. Wang, Chem. Commun., 2020, 56, 7573
DOI: 10.1039/D0CC03158E

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