Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Merging alkenyl C–H activation with the ring-opening of 1,2-oxazetidines: ruthenium-catalyzed aminomethylation of enamides

Author affiliations

Abstract

1,2-Oxazetidines have been utilized as formaldimine precursors for the direct aminomethylation of enamides under a Ru(II) species. By merging alkenyl C–H activation with ring-opening of 1,2-oxazetidines, this efficient protocol provides a facile and novel approach to synthesize Z-selective aminomethyl substituted enamides. Furthermore, two exemplified synthetic elaborations highlight the potential of this transformation.

Graphical abstract: Merging alkenyl C–H activation with the ring-opening of 1,2-oxazetidines: ruthenium-catalyzed aminomethylation of enamides

Back to tab navigation

Supplementary files

Article information


Submitted
28 Apr 2020
Accepted
03 Jun 2020
First published
04 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Merging alkenyl C–H activation with the ring-opening of 1,2-oxazetidines: ruthenium-catalyzed aminomethylation of enamides

S. Li, Q. Shan, L. Hu, X. Ma and X. Hu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03081C

Social activity

Search articles by author

Spotlight

Advertisements