Issue 60, 2020
From the journal:

Chemical Communications

A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells†

Ling Feng,‡abc   Yusheng Xie, ORCID logo ‡*bc   Sung King Au-Yeung,cd   Hagos Birhanu Hailu,cd   Zhiyang Liu, ORCID logo bc   Qingxin Chen,bc   Jie Zhang,bc   Qiuxiang Pang,a   Xi Yao, ORCID logo cd   Mengsu Yang,cd   Liang Zhang*cd  and  Hongyan Sun ORCID logo *bc  

* Corresponding authors

a Cancer and Aging Research Institution, School of Life Science, Shandong University of Technology, China

b Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: yushengxie@outlook.com, hongysun@cityu.edu.hk

c Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, P. R. China

d Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: liangzhang.28@cityu.edu.hk

Abstract

A rotor-based probe MRMP-1 was designed and synthesized. MRMP-1 can bind to plasma membranes very quickly and stably with remarkable fluorescence enhancement. It can be used to monitor the dynamic changes in cell membranes in real-time under stimuli conditions. Importantly, MRMP-1 is the first rotor-based fluorescent sensor to label exosomes in living cells.

Graphical abstract: A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells

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Article information

DOI
https://doi.org/10.1039/D0CC03069D
Article type
Communication
Submitted
28 Apr 2020
Accepted
17 Jun 2020
First published
17 Jun 2020

Chem. Commun., 2020,56, 8480-8483

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A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells

L. Feng, Y. Xie, S. K. Au-Yeung, H. B. Hailu, Z. Liu, Q. Chen, J. Zhang, Q. Pang, X. Yao, M. Yang, L. Zhang and H. Sun, Chem. Commun., 2020, 56, 8480 DOI: 10.1039/D0CC03069D

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