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Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions

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Abstract

In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels–Alder reactions, allowing simultaneous release of two dyes in biological media.

Graphical abstract: Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions

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Article information


Submitted
28 Apr 2020
Accepted
21 May 2020
First published
22 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions

M. Riomet, K. Porte, A. Wijkhuisen, D. Audisio and F. Taran, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC03067H

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