Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 60, 2020
Previous Article Next Article

A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells

Author affiliations

Abstract

Here, a near-infrared (NIR) light-controlled, ultrasensitive one-step photoelectrochemical (PEC) strategy was constructed to simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium–potassium adenosine triphosphatase (Sat), on living cancer cells. Using NIR light as excitation, the signal probe methylene blue (Tagkinetic) could be released, leading to a gradually decreased photocurrent signal Ikinetic; meanwhile, the photocurrent Istable of the signal probe carbon quantum dots (Tagstable) remained stable. The simultaneous detection of Pho and Sat could be achieved based on rapid one-step PEC detection under single NIR light with the assistance of a smart signal decryption strategy with Ikinetic and Istable. Importantly, this proposal provides more effective drug candidates with milder pharmaceutical effect but improved safety.

Graphical abstract: A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells

Back to tab navigation

Supplementary files

Article information


Submitted
25 Apr 2020
Accepted
16 Jun 2020
First published
16 Jun 2020

Chem. Commun., 2020,56, 8488-8491
Article type
Communication

A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells

Y. Zheng, C. Xiong, Y. Zhuo, Y. Chai, W. Liang and R. Yuan, Chem. Commun., 2020, 56, 8488
DOI: 10.1039/D0CC02996C

Social activity

Search articles by author

Spotlight

Advertisements