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Issue 63, 2020
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A short peptide that preferentially binds c-MYC G-quadruplex DNA

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Abstract

G-quadruplexes (G4s) are non-canonical DNA secondary structures. The identification of selective tools to probe individual G4s over the ∼700 000 found in the human genome is key to unravel the biological significance of specific G4s. We took inspiration from a crystal structure of the bovine DHX36 helicase bound to the G4 formed in the promoter region of the oncogene c-MYC to identify a short peptide that preferentially binds MYC G4 with nM affinity over a small panel of parallel and non-parallel G4s tested.

Graphical abstract: A short peptide that preferentially binds c-MYC G-quadruplex DNA

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Supplementary files

Article information


Submitted
23 Apr 2020
Accepted
01 Jul 2020
First published
01 Jul 2020

This article is Open Access

Chem. Commun., 2020,56, 8940-8943
Article type
Communication

A short peptide that preferentially binds c-MYC G-quadruplex DNA

A. Minard, D. Morgan, F. Raguseo, A. Di Porzio, D. Liano, A. G. Jamieson and M. Di Antonio, Chem. Commun., 2020, 56, 8940
DOI: 10.1039/D0CC02954H

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