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Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

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Abstract

We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

Graphical abstract: Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

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Article information


Submitted
23 Apr 2020
Accepted
07 May 2020
First published
07 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

L. Yu, J. F. Zhang, M. Li, D. Jiang, Y. Zhou, P. Verwilst and J. S. Kim, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02943B

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