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Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides

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Abstract

Targeting specific cellular organelles is an elusive therapeutic goal that could be achieved by manipulating nanocrystal facets. As proof of concept, different facet-engineered nanonods (high-energy (001) CdS and (001) CdSe, and low-energy (101) CdS and (110) CdSe) exploited selective binding by organelle-targeting peptides and subsequent intracellular protein sorting to inhibit specific organelles without significant cytotoxicity.

Graphical abstract: Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides

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Article information


Submitted
23 Apr 2020
Accepted
01 Jun 2020
First published
01 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides

Q. Yu, G. Wu, T. Zhang, X. Zhao, Z. Zhou, L. Liu, W. Chen and P. J. J. Alvarez, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02930K

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