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Issue 51, 2020
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Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway

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Abstract

A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S–S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine.

Graphical abstract: Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway

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Submitted
23 Apr 2020
Accepted
18 May 2020
First published
18 May 2020

Chem. Commun., 2020,56, 6981-6984
Article type
Communication

Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway

S. Xiao, W. Lee, F. Chen, P. Y. Zavalij, O. Gutierrez and J. T. Davis, Chem. Commun., 2020, 56, 6981
DOI: 10.1039/D0CC02926B

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