Issue 51, 2020
From the journal:

Chemical Communications

Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway†

Songjun Xiao,*a   Wes Lee,a   Fu Chen,a   Peter Y. Zavalij, ORCID logo a   Osvaldo Gutierrez ORCID logo *a  and  Jeffery T. Davis ORCID logo *a  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA
E-mail: jdavis@umd.edu, sxiao@terpmail.umd.edu, ogs@umd.edu

Abstract

A disulfide made by oxidation of 8-thioguanosine is a supergelator. The hydrogels are redox-responsive, as they disassemble upon either reduction or oxidation of the S–S bond. We also identified this disulfide, and 2 other compounds, as intermediates in oxidative desulfurization of 8-thioG to guanosine.

Graphical abstract: Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway

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Article information

DOI
https://doi.org/10.1039/D0CC02926B
Article type
Communication
Submitted
23 Apr 2020
Accepted
18 May 2020
First published
18 May 2020

Chem. Commun., 2020,56, 6981-6984

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Oxidation of 8-thioguanosine gives redox-responsive hydrogels and reveals intermediates in a desulfurization pathway

S. Xiao, W. Lee, F. Chen, P. Y. Zavalij, O. Gutierrez and J. T. Davis, Chem. Commun., 2020, 56, 6981 DOI: 10.1039/D0CC02926B

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