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Issue 64, 2020
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Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

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Abstract

An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusual dynamic kinetic resolution.

Graphical abstract: Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

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Supplementary files

Article information


Submitted
21 Apr 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020,56, 9094-9097
Article type
Communication

Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

L. M. Azofra, M. A. Tran, V. Zubar, L. Cavallo, M. Rueping and O. El-Sepelgy, Chem. Commun., 2020, 56, 9094
DOI: 10.1039/D0CC02881A

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