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Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

Abstract

An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman’s sulfinamide as versatile ammonia surrogate. DFT calculations explain the unusual finding of the highly stereoselective transformation enabled by a catalyst that undergoes an unusal dynamic kinetic resolution

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Article information


Submitted
21 Apr 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation

L. M. Azofra, M. A. Tran, V. Zubar, L. Cavallo, M. Rueping and O. El-Sepelgy, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC02881A

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