Issue 47, 2020
From the journal:

Chemical Communications

Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine†

Ming Gong, ORCID logo a   Jian Yang,a   Yongsheng Li ORCID logo a  and  Jinlou Gu ORCID logo *a  

* Corresponding authors

a Shanghai Engineering Research Center of Hierarchical Nanomaterials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: jinlougu@ecust.edu.cn

Abstract

A glutathione-triggered drug delivery system (DDS) based on nanoscale metal–organic frameworks (NMOFs) is developed, which features an intracellular redox-responsive release of an anticancer drug. Compared to normal cells, the current NMOF-based DDS has 3-fold higher cytotoxicity to cancer cells, prefiguring its great potential for selective cancer therapy.

Graphical abstract: Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

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Article information

DOI
https://doi.org/10.1039/D0CC02872J
Article type
Communication
Submitted
21 Apr 2020
Accepted
29 Apr 2020
First published
30 Apr 2020

Chem. Commun., 2020,56, 6448-6451

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Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

M. Gong, J. Yang, Y. Li and J. Gu, Chem. Commun., 2020, 56, 6448 DOI: 10.1039/D0CC02872J

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