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Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

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Abstract

A glutathione-triggered drug delivery system (DDS) based on nanoscale metal–organic frameworks (NMOFs) is developed, which features an intracellular redox-responsive release of an anticancer drug. Compared to normal cells, the current NMOF-based DDS has 3-fold higher cytotoxicity to cancer cells, prefiguring its great potential for selective cancer therapy.

Graphical abstract: Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

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Article information


Submitted
21 Apr 2020
Accepted
29 Apr 2020
First published
30 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

M. Gong, J. Yang, Y. Li and J. Gu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02872J

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