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2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

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Abstract

2-Mercaptobenzoxazole is a widely used organic scaffold in medicinal chemistry. By means of kinetic and structural studies, we demonstrate that this molecule can effectively be used to inhibit hCAs showing a peculiar binding mode. The results reported here can pave the way for the development of selective CA inhibitors.

Graphical abstract: 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

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Article information


Submitted
20 Apr 2020
Accepted
12 Jun 2020
First published
23 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site

M. Bozdag, C. T. Supuran, D. Esposito, A. Angeli, F. Carta, S. M. Monti, G. De Simone and V. Alterio, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02857F

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