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Synthesis of 18O-labelled alcohols from unlabelled alcohols

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Abstract

The synthesis of primary, secondary and tertiary 18O-enriched alcohols from readily available 16O-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.

Graphical abstract: Synthesis of 18O-labelled alcohols from unlabelled alcohols

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Article information


Submitted
20 Apr 2020
Accepted
18 May 2020
First published
19 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Synthesis of 18O-labelled alcohols from unlabelled alcohols

R. H. Beddoe, D. C. Edwards, L. Goodman, H. F. Sneddon and R. M. Denton, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC02855J

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